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FEMA 4774

CAS No. 1359963-68-0

FEMA 4774( S9632 )

Catalog No. M22734 CAS No. 1359963-68-0

FEMA 4774 is a positive allosteric modulator of T1R2/T1R3.?FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    FEMA 4774
  • Note
    Research use only, not for human use.
  • Brief Description
    FEMA 4774 is a positive allosteric modulator of T1R2/T1R3.?FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests.
  • Description
    FEMA 4774 is a positive allosteric modulator of T1R2/T1R3.?FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests.
  • In Vitro
    FEMA 4774 (0-50 μM) induces a dose-dependent decrease in the EC50 value of sucrose and significantly enhances the affinity of sucrose for its binding site with an α (effect of modulator on agonist affinity) value of 30 in the human sweet receptor cells.
  • In Vivo
    FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice.The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats.
  • Synonyms
    S9632
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    T1R2/T1R3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1359963-68-0
  • Formula Weight
    359.45
  • Molecular Formula
    C19H25N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 41.67 mg/mL (115.94 )
  • SMILES
    CC(C)NC(=O)C(C)(C)COc1cccc2nc(C)c(C(O)=O)c(N)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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